Warning: this strategy is not for the faint of heart. It's like playing a game of digital whack-a-mole, but with pixels.
Step 1: Locate a cluster of pixels, and then... SQUASH with reckless abandon.
This approach is not for the faint of heart. Proceed with caution, or not. Your choice.
Other Strategies:
minimalist image of a pixelated hammer, with the words "Squash Like You Mean It!" written in bold, black text below.