When you wake up, don't immediately start squashing pixels. Your brain needs time to reboot, and those pixels will still be there when you're ready to squash them.
Try having a nice cup of coffee, take a few deep breaths, and remember that pixelated squashing is a marathon, not a sprint.
But seriously, have you seen the new Pixelator 9000? It's like a timesaving miracle for pixelated squashing!