In the grand tradition of absurdity, Meme Ontology posits that the meaning of a meme is not fixed, but rather it is a constantly evolving, amoeba-like blob of cultural relevance.
However, Meme Hermeneutics suggests that the meaning of a meme can only be truly understood through the lens of its surrounding cultural context, like a surrealist surrealist painting.
And then, of course, there's Meme Dialectics, which posits that the meaning of a meme is always in flux, like a game of telephone played out in an infinite loop.
But, as any self-respecting Meme Nihilist would tell you, the meaning of a meme is, in fact, nothing at all, like a void left in a forgotten toaster.